- Title
- The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis
- Creator
- Teng, Liu; Feng, Yu Chen; Guo, Su Tang; Wang, Pei Lin; Qi, Teng Fei; Yue, Yi Meng; Wang, Shi Xing; Zhang, Sheng Nan; Tang, Cai Xia; La, Ting; Zhang, Yuan Yuan; Zhao, Xiao Hong; Gao, Jin Nan; Wei, Li Yuan; Zhang, Didi; Wang, Jenny Y.; Shi, Yujie; Liu, Xiao Ying; Li, Jin Ming; Cao, Huixia; Thorne, Rick F.; Jin, Lei; Zhang, Xu Dong
- Relation
- NHMRC.APP1147271 http://purl.org/au-research/grants/nhmrc/1147271
- Relation
- Nature Communications Vol. 12, Issue 1, no. 3734
- Publisher Link
- http://dx.doi.org/10.1038/s41467-021-24099-4
- Publisher
- Nature Publishing Group
- Resource Type
- journal article
- Date
- 2021
- Description
- Genomic amplification of the distal portion of chromosome 3q, which encodes a number of oncogenic proteins, is one of the most frequent chromosomal abnormalities in malignancy. Here we functionally characterise a non-protein product of the 3q region, the long noncoding RNA (lncRNA) PLANE, which is upregulated in diverse cancer types through copy number gain as well as E2F1-mediated transcriptional activation. PLANE forms an RNA-RNA duplex with the nuclear receptor co-repressor 2 (NCOR2) pre-mRNA at intron 45, binds to heterogeneous ribonucleoprotein M (hnRNPM) and facilitates the association of hnRNPM with the intron, thus leading to repression of the alternative splicing (AS) event generating NCOR2-202, a major protein-coding NCOR2 AS variant. This is, at least in part, responsible for PLANE-mediated promotion of cancer cell proliferation and tumorigenicity. These results uncover the function and regulation of PLANE and suggest that PLANE may constitute a therapeutic target in the pan-cancer context.
- Subject
- cancer; alternative splicing (AS); PLANE; geonomic; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1457202
- Identifier
- uon:45314
- Identifier
- ISSN:2041-1723
- Rights
- © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
- Language
- eng
- Full Text
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